What is the Role of Metalloprotease MT4-MMP in Melanoma? [06.09.17]
Membrane-type matrix metalloproteinases (MT-MMPs) are expressed on the cell surface and hydrolyze extracellular matrix components and signaling molecules by which they influence cancer cell migration and metastasis.
Melanoma
Researchers from the Institute of Biological Chemistry and Nutrional Sciences demonstrate the novel expression of MT4-MMP in melanocytic tissues and propose a precursor/product-relationship of the different forms of MT4-MMP in melanoma cells.
Original study: Hieronimus B, Pfohl J, Busch C, Graeve L (2017) Expression and Characterization of Membrane-Type 4 Matrix Metalloproteinase (MT4-MMP) and its Different Forms in Melanoma. Cell Physiol Biochem. 2017;42(1):198-210. doi: 10.1159/000477311. Epub 2017 May 25.
