AMP-aktivierte Proteinkinase (AMPK) -abhängige Regulation des renalen Transports [27.11.18]
Eine Vielzahl von Publikationen weist auf die zentrale Rolle von AMPK als metabolisch-sensorischer Regulator einer Vielzahl von Transportprozessen in der Niere hin. Der aktuelle Review von Herrn Professor Föller und einem Kollegen der Universität Halle/Saale fasst die Erkenntnisse zur AMPK-abhängigen Regulation des Membrantransports entlang von Nephronsegmenten zusammen und diskutiert deren physiologische und pathophysiologische Implikationen. Die Autoren betonen die Notwendigkeit weiterer Studien, um das therapeutische Potenzial pharmakologischer AMPK-Interventionen zur Bekämpfung von Nierenerkrankungen zu erschließen (Glosse & Föller et al, 2018)
Originalpublikation
Glosse, Philipp; Föller, Michael (2018): AMP-Activated Protein Kinase (AMPK)-Dependent Regulation of Renal Transport. In: International journal of molecular sciences 19 (11). DOI: 10.3390/ijms19113481.
Author information:
Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, D-06120 Halle (Saale), Germany
Institute of Physiology, University of Hohenheim, Stuttgart, D-70599, Germany
Abstract
AMP-activated kinase (AMPK) is a serine/threonine kinase that is expressed in most cells and activated by a high cellular AMP/ATP ratio (indicating energy deficiency) or by Ca2+. In general, AMPK turns on energy-generating pathways (e.g., glucose uptake, glycolysis, fatty acid oxidation) and stops energy-consuming processes (e.g., lipogenesis, glycogenesis), thereby helping cells survive low energy states. The functional element of the kidney, the nephron, consists of the glomerulus, where the primary urine is filtered, and the proximal tubule, Henle's loop, the distal tubule, and the collecting duct. In the tubular system of the kidney, the composition of primary urine is modified by the reabsorption and secretion of ions and molecules to yield final excreted urine. The underlying membrane transport processes are mainly energy-consuming (active transport) and in some cases passive. Since active transport accounts for a large part of the cell's ATP demands, it is an important target for AMPK. Here, we review the AMPK-dependent regulation of membrane transport along nephron segments and discuss physiological and pathophysiological implications.
