Animal Studies Microbiome: Hohenheim Research Center for Health Sciences

Microbiome Research - Animal Studies and Models

Projects

InsP6 metabolism & the influence of the microbiome and its metabolites on epithelial functions and the contractility of smooth musculature (Huber, K) (2018-2021), more
Projects Dept. Livestock Microbial Ecology: Jun.-Prof. Amélia Camarinha Silva
Projects Dept. Functional Microbiology of Livestock: Prof. Jana Seifert
Projekte im Dept. Animal Nutrition: Prof. Markus Rodehutscord
Hohenheim Center for Livestock Microbiome Research (HoLMiR)
The impact of feed and the environment on intestinal microbiota and parasites in honey bees: Paul d'Alvise/ Prof. Martin Hasselmann.

Publications

Trautmann, Andrej; Schleicher, Lena; Deusch, Simon; Gätgens, Jochem; Steuber, Julia; Seifert, Jana (2020): Short-Chain Fatty Acids Modulate Metabolic Pathways and Membrane Lipids in Prevotella bryantii B14. In: Proteomes 8 (4). DOI: 10.3390/proteomes8040028.
Borda-Molina, D., Roth, C., Hérnandez-Arriaga, A., Rissi, D., Vollmar, S., Rodehutscord, M., Bennewitz, J., Camarinha-Silva, A., 2020. Effects on the Ileal Microbiota of Phosphorus and Calcium Utilization, Bird Performance, and Gender in Japanese Quail. Animals 10, 885. doi.org/10.3390/ani10050885
Ponsuksili, S., Reyer, H., Hadlich, F., Weber, F., Trakooljul, N., Oster, M., Siengdee, P., Muráni, E., Rodehutscord, M., Camarinha-Silva, A., Bennewitz, J., Wimmers, K., 2020. Identification of the Key Molecular Drivers of Phosphorus Utilization Based on Host miRNA-mRNA and Gut Microbiome Interactions. International Journal of Molecular Sciences 21, 2818. doi.org/10.3390/ijms21082818
Seeburger, V.C., D’Alvise, P., Shaaban, B., Schweikert, K., Lohaus, G., Schroeder, A., Hasselmann, M., 2020. The trisaccharide melezitose impacts honey bees and their intestinal microbiota. PLOS ONE 15, e0230871. doi.org/10.1371/journal.pone.0230871
Pineda-Quiroga, Carolina; Borda-Molina, Daniel; Chaves-Moreno, Diego; Ruiz, Roberto; Atxaerandio, Raquel; Camarinha-Silva, Amélia; García-Rodríguez, Aser (2019): Microbial and Functional Profile of the Ceca from Laying Hens Affected by Feeding Prebiotics, Probiotics, and Synbiotics. In: Microorganisms 7 (5). DOI: 10.3390/microorganisms7050123.
Hernández-Arriaga, Angélica; Baumann, Anja; Witte, Otto W.; Frahm, Christiane; Bergheim, Ina; Camarinha-Silva, Amélia (2019): Changes in Oral Microbial Ecology of C57BL/6 Mice at Different Ages Associated with Sampling Methodology. In: Microorganisms 7 (9). DOI: 10.3390/microorganisms7090283.
Sommerfeld, Vera; van Kessel, Andrew G.; Classen, Henry L.; Schollenberger, Margit; Kühn, Imke; Rodehutscord, Markus (2019): Phytate degradation in gnotobiotic broiler chickens and effects of dietary supplements of phosphorus, calcium, and phytase. In: Poultry science 98 (11), S. 5562–5570. DOI: 10.3382/ps/pez309.
Borda-Molina, D.; Zuber, T.; Siegert, W.; Camarinha-Silva, A.; Feuerstein, D.; Rodehutscord, M. (2019): Effects of protease and phytase supplements on small intestinal microbiota and amino acid digestibility in broiler chickens. In: Poultry science 98 (7), S. 2906–2918. DOI: 10.3382/ps/pez038.
Tröscher-Mußotter, Johanna; Tilocca, Bruno; Stefanski, Volker; Seifert, Jana (2019): Analysis of the Bacterial and Host Proteins along and across the Porcine Gastrointestinal Tract. In: Proteomes 7 (1). DOI: 10.3390/proteomes7010004.
Li, Lu; Guo, Wei-Ling; Zhang, Wen; Xu, Jia-Xin; Qian, Min; Bai, Wei-Dong et al. (2019): Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats. In: Food & function 10 (5), S. 2560–2572. DOI: 10.1039/c9fo00075e.
Brandt, Annette; Hernández-Arriaga, Angélica; Kehm, Richard; Sánchez, Victor; Jin, Cheng Jun; Nier, Anika et al. (2019): Metformin attenuates the onset of non-alcoholic fatty liver disease and affects intestinal microbiota and barrier in small intestine. In: Scientific reports 9 (1), S. 6668. DOI: 10.1038/s41598-019-43228-0.
Heyer, Charlotte Maria Elisabeth, Schmucker, Sonja, Burbach, Weiss, E Katharina, Eklund, Meike, Aumiller, Tobias, Capezzone, Filippo, Steuber, Julia, Rodehutscord, Markus, Hoelzle, Ludwig. Seifert, Jana, Mosenthin, Rainer & Stefanski, Volker. (2019). Phytate degradation, intestinal microbiota, microbial metabolites and immune values are changed in growing pigs fed diets with varying calcium–phosphorus concen E.tration and fermentable substrates. Journal of Animal Physiology and Animal Nutrition. 10.1111/jpn.13088.
Wassie, Shimels Eshete; Ali, Asep Indra Munawar; Korir, Daniel; Butterbach-Bahl, Klaus; Goopy, John; Merbold, Lutz et al. (2019): Effects of feed intake level on efficiency of microbial protein synthesis and nitrogen balance in Boran steers consuming tropical poor-quality forage. In: Archives of animal nutrition 73 (2), S. 140–157. DOI: 10.1080/1745039X.2019.1572343.
Bromberg, Jonathan S.; Hittle, Lauren; Xiong, Yanbao; Saxena, Vikas; Smyth, Eoghan M.; Li, Lushen et al. (2018): Gut microbiota-dependent modulation of innate immunity and lymph node remodeling affects cardiac allograft outcomes. In: JCI insight 3 (19). DOI: 10.1172/jci.insight.121045.
Heyer, Charlotte Maria Elisabeth; Schmucker, Sonja; Burbach, Katharina; Weiss, Eva; Eklund, Meike; Aumiller, Tobias et al. (2019): Phytate degradation, intestinal microbiota, microbial metabolites and immune values are changed in growing pigs fed diets with varying calcium-phosphorus concentration and fermentable substrates. In: Journal of Animal Physiology and Animal Nutrition. DOI: 10.1111/jpn.13088.
Borda-Molina D, Zuber T, Siegert W, Camarinha-Silva A, Feuerstein D, Rodehutscord M.(2019) Effects of protease and phytase supplements on small intestinal microbiota and amino acid digestibility in broiler chickens. Poult Sci. 2019 Feb 15. pii: pez038. doi: 10.3382/ps/pez038. [Epub ahead of print]
Wassie SE, Ali AIM, Korir D, Butterbach-Bahl K, Goopy J, Merbold L, Schlecht E, Dickhoefer U.(2019) Effects of feed intake level on efficiency of microbial protein synthesis and nitrogen balance in Boran steers consuming tropical poor-quality forage. Arch Anim Nutr. 2019 Apr;73(2):140-157. doi: 10.1080/1745039X.2019.1572343. Epub 2019 Feb 20.
Siegert, Wolfgang; Ganzer, Christian; Kluth, Holger; Rodehutscord, Markus (2019): Effect of amino acid deficiency on precaecal amino acid digestibility in broiler chickens. In: Journal of Animal Physiology and Animal Nutrition. DOI: 10.1111/jpn.13066.
Sylvain Normand, Nadine Waldschmitt, Andreas Neerincx, Ruben Julio Martinez-Torres, Camille Chauvin, Aurélie Couturier-Maillard, Olivier Boulard, Laetitia Cobret, Fawaz Awad, Ludovic Huot, Andre Ribeiro-Ribeiro, Katja Lautz, Richard Ruez,1 Myriam Delacre,1 Clovis Bondu,1 Martin Guilliams,8,9 Charlotte Scott,8,9 Anthony Segal,4 Serge Amselem, David Hot, Sonia Karabina, Erwin Bohn, Bernhard Ryffel, Lionel F. Poulin, Thomas A. Kufer, and Mathias Chamaillardcorresponding author#1(2018): Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens. In: Nature communications 9 (1), S. 5338. DOI: 10.1038/s41467-018-07750-5.
Castro-Montoya, Joaquín; Witzig, Maren; Rahman, Mizanur; Westreicher-Kristen, Edwin; Dickhoefer, Uta (2018): In vitro rumen fermentation, microbial protein synthesis and composition of microbial community of total mixed rations replacing maize silage with red clover silage. In: Journal of Animal Physiology and Animal Nutrition. DOI: 10.1111/jpn.12970.
Kand, D., Bagus Raharjo, I., Castro-Montoya, J., Dickhoefer, U. (2018) The effects of rumen nitrogen balance on in vitro rumen fermentation and microbial protein synthesis vary with dietary carbohydrate and nitrogen source. Animal Feed Science and Technology, 241, pp. 184-197.
D’Alvise, Paul; Böhme, Franziska; Codrea, Marius Cosmin; Seitz, Alexander; Nahnsen, Sven; Binzer, Mieke (...), Rosenkranz, P., Hasselmann, M. (2018): The impact of winter feed type on intestinal microbiota and parasites in honey bees. In: Apidologie 49 (2), S. 252–264. DOI: 10.1007/s13592-017-0551-1.
Borda-Molina, D; Seifert, J; Camarinha Silva, A. (2018): Current Perspectives of the Chicken Gastrointestinal Tract and Its Microbiome. In: Computational and Structural Biotechnology Journal 16, S. 131–139. DOI: 10.1016/j.csbj.2018.03.002.
Siegert, W; Ganzer, C; Kluth, H; Rodehutscord M (2018): Influence of feed provisioning prior to digesta sampling on precaecal amino acid digestibility in broiler chickens. In: Archives of animal nutrition, S. 1–15. DOI: 10.1080/1745039X.2018.1446810.
Krieg, J.; Seifried, N.; Steingass, H.; Rodehutscord M. (2018): In situ and in vitro evaluation of crude protein degradation and utilisable crude protein content of barley, rye and triticale grains for ruminants. In: Journal of Animal Physiology and Animal Nutrition 102 (2), S. 452–461. DOI: 10.1111/jpn.12767.
Pineda-Quiroga C1, Camarinha-Silva, Amélia, Borda-Molina D, Atxaerandio R, Ruiz R, García-Rodríguez A. Feeding broilers with dry whey powder and whey protein concentrate affected productive performance, ileal digestibility of nutrients and cecal microbiota community. Animal. 2018 Apr;12(4):692-700. doi: 10.1017/S1751731117002208. Epub 2017 Sep 7.
Witzig M, Zeder M, Rodehutscord M. Effect of the ionophore monensin and tannin extracts supplemented to grass silage on populations of ruminal cellulolytics and methanogens in vitro. Anaerobe. 2018;50:44–54. doi:10.1016/j.anaerobe.2018.01.012.
Tilocca B; Burbach, Katharina; Heyer, Charlotte M. E.; Hoelzle, Ludwig E.; Mosenthin R; Stefanski, Volker et al. (2017): Dietary changes in nutritional studies shape the structural and functional composition of the pigs' fecal microbiome-from days to weeks. In: Microbiome 5 (1), S. 144. DOI: 10.1186/s40168-017-0362-7.
Burbach K, Strang EJP, Mosenthin R, Camarinha Silva, A., Seifert J: Porcine intestinal microbiota is shaped by diet composition based on rye or triticale.J Appl Microbiol. 2017 Sep 27. doi: 10.1111/jam.13595. [Epub ahead of print]
Deusch, S., Camarinha Silva, A.., Conrad, J., Beifuss, U., Rodehutscord M., Seifert J.: A structural and functional elucidation of the rumen microbiome influenced by various diets and microenvironments (2017) Frontiers in Microbiology , 8 ( AUG ) , art. no. 1605
Heinritz SN, Weiss E, Seifert J, Mosenthin R,, Kuß S, Degenhardt AG, Koch TJ. (2017) Effect of cellobiose supplementation on in vitro fermentation activity and bacterial numbers of porcine inocula. J Anim Physiol Anim Nutr (Berl). 2017 Jul 15. doi: 10.1111/jpn.12770.
Camarinha Silva, A., Maushammer M, Wellmann R, Vital M, Preuss S, Bennewitz, J. (2017) Host Genome Influence on Gut Microbial Composition and Microbial Prediction of Complex Traits in Pigs. Genetics. 2017 Jul;206(3):1637-1644. doi: 10.1534/genetics.117.200782. Epub 2017 May 3.
Heinritz, S.N., Weiss, E., Seifert J, Mosenthin R., Kuß, S., Degenhardt, A.G., Koch, T.J..Effect of cellobiose supplementation on in vitro fermentation activity and bacterial numbers of porcine inocula (2017) J Anim Physiol Anim Nutr (Berl). 2017 Jul 15. doi: 10.1111/jpn.12770.
Camarinha Silva, A., Maushammer, M., Wellmann, R., Vital, M., Preuss, S., Bennewitz, J. Host genome influence on gut microbial composition and microbial prediction of complex traits in pigs (2017) Genetics , 206 ( 3 ) pp. 1637 - 1644
Borda-Molina D, Vital M, Sommerfeld V, Rodehutscord M, Camarinha Silva A. Insights into broilers' gut microbiota fed with phosphorus, calcium, and phytase supplemented diets. Frontiers in Microbiology 2016. doi:10.3389/fmicb.2016.02033.
Burbach K, Seifert J, Pieper DH, Camarinha Silva, A. Evaluation of DNA extraction kits and phylogenetic diversity of the porcine gastrointestinal tract based on Illumina sequencing of two hypervariable regions. MicrobiologyOpen 2016;5:70–82. doi:10.1002/mbo3.312.
Rausch P, Basic M, Batra A, Bischoff SC, Blaut M, Clavel T, et al. Analysis of factors contributing to variation in the C57BL/6J fecal microbiota across German animal facilities. Int J Med Microbiol 2016. doi:10.1016/j.ijmm.2016.03.004. [in press]
Weiss E, Aumiller T, Spindler HK, Rosenfelder P, Eklund M, Witzig M, et al. Wheat and barley differently affect porcine intestinal microbiota. J Sci Food Agric 2016;96:2230–9. doi:10.1002/jsfa.7340.
Aumiller T, Mosenthin R, Weiss E. Potential of cereal grains and grain legumes in modulating pigs׳ intestinal microbiota – A review. Livestock Science 2015;172:16–32. doi:10.1016/j.livsci.2014.11.016.
Deusch S, Seifert J. Catching the tip of the iceberg - Evaluation of sample preparation protocols for metaproteomic studies of the rumen microbiota. Proteomics 2015;15:3590–5. doi:10.1002/pmic.201400556.
Deusch S, Tilocca B, Camarinha Silva A, Seifert J. News in livestock research - use of Omics-technologies to study the microbiota in the gastrointestinal tract of farm animals. Comput Struct Biotechnol J 2015;13:55–63. doi:10.1016/j.csbj.2014.12.005.
Fricke WF, Song Y, Wang A, Smith A, Grinchuk V, Pei C, et al. Type 2 immunity-dependent reduction of segmented filamentous bacteria in mice infected with the helminthic parasite Nippostrongylus brasiliensis. Microbiome 2015;3:40. doi:10.1186/s40168-015-0103-8.
Henderson G, Cox F, Ganesh S, Jonker A, Young W, Janssen PH et al. Rumen microbial community composition varies with diet and host, but a core microbiome is found across a wide geographical range. Sci Rep 2015;5:14567. doi:10.1038/srep14567. [Coauthor: Maren Witzig, Institute of Animal Nutrition]
Heyer CME, Weiss E, Schmucker S, Rodehutscord M, Hoelzle LE, Mosenthin R, Stefanski V. The impact of phosphorus on the immune system and the intestinal microbiota with special focus on the pig. Nutr Res Rev 2015;28:67–82. doi:10.1017/S0954422415000049.
Heyer CME, Weiss E, Schmucker S, Eklund M, Aumiller T, Gräter E, et al. Dietary calcium phosphate content and protein source influence saccharolytic bacteria and the immune system in pigs: 13. Tagung Schweine- und Geflügelernährung, 24.-26.11.2015, Wittenberg.
Witzig M, Boguhn J, Zeder M, Seifert J, Rodehutscord M Effect of donor animal species and their feeding on the composition of the microbial community establishing in a rumen simulation. J Appl Microbiol 2015;119:33–46. doi:10.1111/jam.12829.
Witzig M, Camarinha da Silva A, Green-Engert R, Hoelzle K, Zeller E, Seifert J, Hoelzle LE, Rodehutscord M, Brusetti L. Spatial Variation of the Gut Microbiota in Broiler Chickens as Affected by Dietary Available Phosphorus and Assessed by T-RFLP Analysis and 454 Pyrosequencing. PLoS ONE 2015;10:e0143442. doi:10.1371/journal.pone.0143442.
Rist VTS, Weiss E, Sauer N, Mosenthin R, Eklund M. Effect of dietary protein supply originating from soybean meal or casein on the intestinal microbiota of piglets. Anaerobe 2014;25:72–9. doi:10.1016/j.anaerobe.2013.10.003.
Heinritz SN, Mosenthin R, Weiss E. Use of pigs as a potential model for research into dietary modulation of the human gut microbiota. Nutr Res Rev 2013;26:191–209.
Sauer N, Eklund M, Bauer E, Ganzle MG, Field CJ, Zijlstra RT, Mosenthin R The effects of pure nucleotides on performance, humoral immunity, gut structure and numbers of intestinal bacteria of newly weaned pigs. J Anim Sci 2012;90:3126–34.doi:10.2527/jas.2011-4417.
Metzler-Zebeli BU, Zijlstra RT, Mosenthin R, Ganzle MG. Dietary calcium phosphate content and oat beta-glucan influence gastrointestinal microbiota, butyrate-producing bacteria and butyrate fermentation in weaned pigs. FEMS Microbiol Ecol 2011;75:402–13. doi:10.1111/j.1574-6941.2010.01017.x.
Metzler-Zebeli BU, Hooda S, Pieper R, Zijlstra RT, van Kessel AG, Mosenthin R, Ganzle MG. Nonstarch polysaccharides modulate bacterial microbiota, pathways for butyrate production, and abundance of pathogenic Escherichia coli in the piggastrointestinal tract. Appl Environ Microbiol 2010;76:3692–701. doi:10.1128/AEM.00257-10.
Metzler-Zebeli BU, Vahjen W, Baumgartel T, Rodehutscord M, Mosenthin R. Ileal microbiota of growing pigs fed different dietary calcium phosphate levels and phytase content and subjected to ileal pectin infusion. J Anim Sci 2010;88:147–58. doi:10.2527/jas.2008-1560.