Humanstudien: Hohenheim Research Center for One Health Sciences

Mikrobiom Humanstudien an der UHOH

Projekte

Einfluss fruktosereicher Diäten auf das metabolomische Profil und die Darmmikrobiota von übergewichtigen und normalgewichtigen Frauen (Bischoff, SC/Loius, S.), mehr
Fecal microbiota transplantation (Fricke, F.W. / Dutta, Sudhir, MD) (laufend), mehr
Stomach Microbiota (Fricke, F.W. / Gorkiewicz, G) (laufend), mehr
Aging-associated modification of intestinal homeostasis and barrier function: Role of microbiota, iNOS and innate immunity (Camarinha Silva, A) - DFG SPP 1656
Projektbeginn: 01.08.2015, mehr
Modulation der intestinalen Barriere durch die intestinale Mikrobiota - Rolle von Ernährungsfaktoren und mukosalem Immunsystem (Bischoff, SC) (2013-2016)
(DFG – Schwerpunktprogramm: SPP 1656: Intestinale Mikrobiota - Ein mikrobielles Ökosystem an der Grenze zwischen Immunhomöostase und Entzündung – Förderung seit 2013)
Metabolomics und Mikrobiotaanalyse bei Frauen mit erhöhtem Brustkrebsrisiko (LIBRE-Studie: Lebenstilintervention bei gesunden und erkrankten BRCA1/2 Mutationsträgerinnen und Frauen mit einem hohen Risiko für Brust- und Eierstockkrebs) (Bischoff, SC/Loius, S.) (Deutsche Krebshilfe, 2013-2016), mehr

Publikationen

Beisner, Julia; Gonzalez-Granda, Anita; Basrai, Maryam; Damms-Machado, Antje; Bischoff, Stephan C. (2020): Fructose-Induced Intestinal Microbiota Shift Following Two Types of Short-Term High-Fructose Dietary Phases. In: Nutrients 12 (11). DOI: 10.3390/nu12113444.
Rodriguez, J., Neyrinck, A.M., Zhang, Z., Seethaler, B., Nazare, J.-A., Sánchez, C.R., Roumain, M., Muccioli, G.G., Bindels, L.B., Cani, P.D., Maquet, V., Laville, M., Bischoff, S.C., Walter, J., Delzenne, N.M., 2020. Metabolite profiling reveals the interaction of chitin-glucan with the gut microbiota. Gut Microbes 12, 1810530. doi.org/10.1080/19490976.2020.1810530
Nguyen, N.K., Deehan, E.C., Zhang, Z., Jin, M., Baskota, N., Perez-Muñoz, M.E., Cole, J., Tuncil, Y.E., Seethaler, B., Wang, T., Laville, M., Delzenne, N.M., Bischoff, S.C., Hamaker, B.R., Martínez, I., Knights, D., Bakal, J.A., Prado, C.M., Walter, J., 2020. Gut microbiota modulation with long-chain corn bran arabinoxylan in adults with overweight and obesity is linked to an individualized temporal increase in fecal propionate. Microbiome 8, 118. doi.org/10.1186/s40168-020-00887-w
Schmalle, Victor; Lorentz, Axel (2020): Role of the microbiota in circadian rhythms of the host. In: Chronobiology international, S. 1–10. DOI: 10.1080/07420528.2020.1726374.
Neyrinck, A. M.; Rodriguez, J.; Vinoy, S.; Maquet, V.; Walter, J.; Bischoff, S. C. et al. (2020): The FiberTAG project. Tagging dietary fibre intake by measuring biomarkers related to the gut microbiota and their interest for health. In: Nutr Bull 45 (1), S. 59–65. DOI: 10.1111/nbu.12416.
Krishnamoorthy, Srinivasan; Coetzee, Vinet; Kruger, Johanita; Potgieter, Hanneke; Buys, Elna M. (2020): Dysbiosis Signatures of Fecal Microbiota in South African Infants with Respiratory, Gastrointestinal, and other Diseases. In: The Journal of pediatrics. DOI: 10.1016/j.jpeds.2019.11.029.
Bischoff, Stephan C. (2019): Verdauungsoptimierung – wie sich Ernährung und Mikrobiom gegenseitig beeinflussen. In: Deutsche medizinische Wochenschrift (1946) 144 (14), S. 943–948. DOI: 10.1055/a-0826-1977.
Bischoff, S. C. (2019): Ernährung und Darmmikrobiom. In: Gastroenterologe 352 (4), S. 532. DOI: 10.1007/s11377-019-0342-5.
Deusch S, Serrano-Villar S, Rojo D, Martínez-Martínez M, Bargiela R, Vázquez-Castellanos JF, Sainz T, Barbas C, Moya A, Moreno S, Gosalbes MJ, Estrada V, Seifert J, Ferrer M. (2018) Effects of HIV, ART and prebiotics on the active fraction of the gut microbiota. AIDS. 2018 Apr 19. doi: 10.1097/QAD.0000000000001831. [Epub ahead of print] | AIDS: June 19, 2018 - Volume 32 - Issue 10 - p 1229–1237
Trautvetter U, Camarinha-Silva A, Jahreis G, Lorkowski S, Glei M. High phosphorus intake and gut-related parameters - results of a randomized placebo-controlled human intervention study. Nutr J. 2018;17:23. doi:10.1186/s12937-018-0331-4.
Nier A, Engstler AJ, Maier IB, Bergheim I: Markers of intestinal permeability are already altered in early stages of non-alcoholic fatty liver disease: Studies in children. PLoS One. 2017 Sep 7;12(9):e0183282. doi: 10.1371/journal.pone.0183282. eCollection 2017.
Bischoff SC. Microbiota and aging. Curr Opin Clin Nutr Metab Care 2016;19:26–30. doi:10.1097/MCO.0000000000000242.
Louis S, Tappu R, Damms-Machado A, Huson DH, Bischoff SC. Characterization of the Gut Microbial Community of Obese Patients Following a Weight-Loss Intervention Using Whole Metagenome Shotgun Sequencing. PLoS ONE 2016;11:e0149564. doi:10.1371/journal.pone.0149564.
Serrano-Villar S, Rojo D, Martinez-Martinez M, Deusch S, Vazquez-Castellanos JF, Bargiela R, et al. Gut Bacteria Metabolism Impacts Immune Recovery in HIV-infected Individuals. EBioMedicine 2016;8:203–16. doi:10.1016/j.ebiom.2016.04.033. [Co-Author: Jana Seifert].
Serrano-Villar S, Rojo D, Martinez-Martinez M, Deusch S, Vazquez-Castellanos JF, Sainz T, et al. HIV infection results in metabolic alterations in the gut microbiota different from those induced by other diseases. Sci Rep 2016;6:26192. doi:10.1038/srep26192. [Co-Author: Jana Seifert].
Bromberg JS, Fricke WF, Brinkman CC, Simon T, Mongodin EF. Microbiota—implications for immunity and transplantation. Nat Rev Nephrol 2015;11:342–53. doi:10.1038/nrneph.2015.70.
Damms-Machado A, Mitra S, Schollenberger AE, Kramer KM, Meile T, Königsrainer A, et al. Effects of surgical and dietary weight loss therapy for obesity on gut microbiota composition and nutrient absorption. Biomed Res Int 2015;2015:806248. doi:10.1155/2015/806248.
Bischoff SC, Barbara G, Buurman W, Ockhuizen T, Schulzke J, Serino M, et al. Intestinal permeability – a new target for disease prevention and therapy. BMC Gastroenterol 2014;14:189. doi:10.1186/s12876-014-0189-7.
Dutta SK, Girotra M, Garg S, Dutta A, Rosenvinge EC von, Maddox C, et al. Efficacy of combined jejunal and colonic fecal microbiota transplantation for recurrent clostridium difficile infection. Clin Gastroenterol Hepatol 2014;12:1572–6. doi:10.1016/j.cgh.2013.12.032. [Coauthor: Fricke WF]
Fricke WF, Maddox C, Song Y, Bromberg JS. Human microbiota characterization in the course of renal transplantation. Am J Transplant 2014;14:416–27. doi:10.1111/ajt.12588.
Hernández E, Bargiela R, Diez MS, Friedrichs A, Perez-Cobas AE, Gosalbes MJ, et al. Functional consequences of microbial shifts in the human gastrointestinal tract linked to antibiotic treatment and obesity. Gut Microbes 2013;4:306–15. doi:10.4161/gmic.25321. [Coauthor: Jana Seifert, Institute of Animal Nutrition]
Rosenvinge EC von, Song Y, White JR, Maddox C, Blanchard T, Fricke WF. Immune status, antibiotic medication and pH are associated with changes in the stomach fluid microbiota. ISME J 2013;7:1354–66. doi:10.1038/ismej.2013.33.
Bischoff SC. Probiotika an der Nahtstelle zwischen Ernährung, intestinalem Mikrobiom und Immunsystem. Medizinische Welt 2009;60:237–40 [Probiotics at the junction between nutrition, intestinal microbiome and immune system]